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Anita Mahadevan-Jansen

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Anita Mahadaven-Jansen
Alma materUniversity of Mumbai (BSc, MS)
University of Texas at Austin (MS, PhD)
Known forClinical Biophotonics
Surgical Guidance
Cancer Detection
Raman Spectroscopy
Fluorescence Spectroscopy
Neuromodulation
AwardsFellow of SPIE
Fellow of the Optical Society
Fellow of the Society for Applied Spectroscopy
Fellow of the American Society of Lasers in Medicine and Surgery
Fellow of the American Institute for Medical and Biological Engineering
Scientific career
FieldsBiomedical Engineering
Physics
Optics
Biophotonics
InstitutionsVanderbilt University
Doctoral advisorRebecca Richards-Kortum
Websitewww.vanderbilt.edu/vbc

Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, The Optical Society, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery.[1] She was elected to serve as the 2020 Vice President of SPIE. With her election, Mahadevan-Jansen joined the SPIE presidential chain and served as President-Elect in 2021 and the Society's President in 2022.[2]

Early life and education

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As a child Mahadevan-Jansen wanted to be a medical doctor.[3] She studied physics at the University of Mumbai, and earned her Bachelor's and master's degree there in 1990.[3] As an undergraduate student she was disinterested in optics.[4] Her professor, S.B. Patel, proposed that she applied to work in biomedical engineering.[3][4] She moved to the University of Texas at Austin for her doctoral studies, where she completed a Master's and PhD in 1996.[5][6] There, she began working with fluorescence spectroscopy under the supervision of Rebecca Richards-Kortum.[3]

Research and career

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Mahadevan-Jansen joined the faculty at Vanderbilt University in 1996 and is currently Orrin H. Ingram Professor of Biomedical Engineering, Professor of Neurological Surgery.[7] She founded the Vanderbilt Biophotonics Center, where she works on optical diagnostics, surgical guidance, and neurophotonics.[8][9] She is interested in translating optical technologies into in vivo diagnostic tools.[10] Mahadevan-Jansen pioneered the use of in vivo Raman spectroscopy for non-invasive diagnostics cervical dysplasia.[11] Her methodology is being developed for use in clinical medicine, for example, it may be used by surgeons in the treatment of breast and brain cancer.[12] She created optical blood testing methodologies for neonatal babies, which was selected by the Vanderbilt University Center for Technology Transfer as one of the "coolest inventions" of the year.[13] She developed sensors that can detect inflammation caused by bowel disease into a typical colonoscopy procedure.[14]

In 2005, Dr. Mahadevan-Jansen and collaborators (including her husband, Dr. E Duco Jansen[15]) discovered the ability to control peripheral and central nervous system electrical activity label-free with short pulses of infrared light.[16] Termed infrared neural stimulation (INS), the field of label-free neuromodulation has evolved over the last decade built on these initial findings.[17] This technology has demonstrated as safe and clinically translatable in humans.[18]

In 2014, Mahadevan-Jansen was elected as conference co-chair to the 2018 Gordon Research Conference on Lasers in Medicine Biology with Paul French. She is exploring the use of Raman spectroscopy for investigating pre-term cervical remodeling.[11] In 2018, 10 years after Mahadevan-Jensen demonstrated that parathyroid gland tissues glow under near-infrared light, the Food and Drug Administration approved that the technology could be used for surgeries.[19][20] Her technology, the PTeye, was tested in a 81 patient clinical trial, and enables in situ monitoring of the parathyroid tissue during thyroid surgery.[19] Before Mahadevan-Jansen's technology, surgeons relied on a visual assessment to identify the location of the parathyroid gland.[19] She is also working on a development of Raman spectroscopy for the early diagnosis of throat cancer related to HPV.[21] She leads a $3 million Vanderbilt University program that develops microscopy tools.[12] Both projects are part of the Trans-Institutional Programs (TIPs) program at Vanderbilt University.[21]

Since 1995, Mahadevan-Jansen is listed as co-inventor on more than 20 USPTO patents, several of which being licensed towards commercial development.[22]

Academic service

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Dr. Mahadevan-Jansen has served as a reviewer for nearly two dozen journals over her career, including her role on the editorial board for the Journal of Biomedical Optics from 2007 to 2014. She started the Biomedical Vibrational Spectroscopy conference at SPIE's Photonics West BiOS conference in 2002, which has been running ever since.[23] In 2007 she featured in the SPIE Women in Optics planner.[24] Her advocacy for improving diversity and inclusion in optics and photonics has led to her chairing the SPIE Equity, Diversity, and Inclusion Committee.[25] She is a Fellow of SPIE and served on the Board of Directors from 2014 to 2019.[26][27] In 2014 Mahadaevan-Jansen was the second woman to be elected Chair of the Gordon Research Conference on Lasers in Medicine & Biology.[28] She also serves as a Fellow of The Optical Society and the American Institute for Medical and Biological Engineering.[29][30] She and her students have received numerous awards for research excellence and mentoring, for which she remains a strong advocate.[31]

Selected publications

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Her publications include;

  • Mahadevan-Jansen, Anita (2019). "Raman microspectroscopy differentiates perinatal pathogens on ex vivo infected human fetal membrane tissues". Journal of Biophotonics. e201800449 (9): e201800449. doi:10.1002/jbio.201800449. PMC 6902120. PMID 31162821.
  • Mahadevan-Jansen, Anita (2019). "Enhancing Parathyroid Gland Visualization Using a Near Infrared Fluorescence-Based Overlay Imaging System". Journal of the American College of Surgeons. 228 (5): 730–743. doi:10.1016/j.jamcollsurg.2019.01.017. PMC 6487208. PMID 30769112.
  • Mahadevan-Jansen, Anita (2018). "Development of a visually guided Raman spectroscopy probe for cervical assessment during pregnancy". Journal of Biophotonics. 12 (2): e201800138. doi:10.1002/jbio.201800138. PMC 6578580. PMID 30259692.

Personal life

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Mahadevan-Jansen is married to Duco Jansen, a Professor of Biomedical Engineering at Vanderbilt University.[3] Together they have two children.[32]

References

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  1. ^ "Anita Mahadevan-Jansen, PhD – Beckman Laser Institute". Retrieved 2019-08-11.
  2. ^ "Anita Mahadevan-Jansen of Vanderbilt University elected to SPIE presidential chain".
  3. ^ a b c d e "Anita Mahadevan-Jansen, Ph.D. 1996". UTexas. Retrieved 2019-08-11.
  4. ^ a b "Anita Mahadevan-Jansen - 2007 SPIE Women in Optics Planner". spie.org. Retrieved 2019-08-11.
  5. ^ "Mahadevan-Jansen [1096] | Vanderbilt-Ingram Cancer Center". www.vicc.org. Retrieved 2019-08-11.
  6. ^ Oldenburg, A. L.; Chen, Y.; Krapf, D.; Mahadevan-Jansen, A.; Rolland, J.; Tunnell, J. (2016). "Introduction to the Issue on Biophotonics". IEEE Journal of Selected Topics in Quantum Electronics. 22 (3): 4–6. Bibcode:2016IJSTQ..22....4O. doi:10.1109/JSTQE.2016.2562238. ISSN 1077-260X.
  7. ^ "Bio". School of Engineering. Retrieved 2019-08-14.
  8. ^ "Anita Mahadevan-Jansen". Vanderbilt Biophotonics Center. Retrieved 2019-08-11.
  9. ^ "Engineering dean announces creation of Biophotonics Center at Vanderbilt". Vanderbilt University. Retrieved 2019-08-12.
  10. ^ "Anita Mahadevan-Jansen". Vanderbilt Biophotonics Center. Retrieved 2019-08-14.
  11. ^ a b "Device in Use for Pre-term Birth". www.wsmv.com. Retrieved 2019-08-11.
  12. ^ a b "Biomedical Microscopy – Immersion, Innovation, Discovery (BioMIID) at VBC". Vanderbilt University. Retrieved 2019-08-14.
  13. ^ "Engineers lead 6 of 10 'cool inventions' of 2014: CTTC". Vanderbilt University. Retrieved 2019-08-12.
  14. ^ "Researchers' sensor integrates inflammatory bowel disease detection into colonoscopy procedure". Vanderbilt University. Retrieved 2019-08-12.
  15. ^ "Bio". School of Engineering. Retrieved 2019-08-15.
  16. ^ Mahadevan-Jansen, Anita; M.d, Peter E. Konrad; Jansen, E. Duco; M.d, Chris Kao; Wells, Jonathon D. (November 2005). "Application of infrared light for in vivo neural stimulation". Journal of Biomedical Optics. 10 (6): 064003. Bibcode:2005JBO....10f4003W. doi:10.1117/1.2121772. ISSN 1083-3668. PMID 16409069. S2CID 15714776.
  17. ^ Roe, Anna Wang; Chen, Gang; Zhang, Xiaotong; Mahadevan-Jansen, Anita; Jansen, E. Duco; Cayce, Jonathan M.; Chernov, Mykyta M.; Sun, Yi; Song, Xuemei (2019-04-01). "Focal infrared neural stimulation with high-field functional MRI: A rapid way to map mesoscale brain connectomes". Science Advances. 5 (4): eaau7046. Bibcode:2019SciA....5.7046X. doi:10.1126/sciadv.aau7046. ISSN 2375-2548. PMC 6482007. PMID 31032400.
  18. ^ Cayce, Jonathan M.; Wells, Jonathon D.; Malphrus, Jonathan D.; Kao, Chris; Thomsen, Sharon; Tulipan, Noel B.; Konrad, Peter E.; Jansen, E. Duco; Mahadevan-Jansen, Anita (January 2015). "Infrared neural stimulation of human spinal nerve roots in vivo". Neurophotonics. 2 (1): 015007. doi:10.1117/1.NPh.2.1.015007. ISSN 2329-423X. PMC 4478764. PMID 26157986.
  19. ^ a b c "FDA approves device based on Vanderbilt invention to ID parathyroid during head and neck surgeries". Vanderbilt University. Retrieved 2019-08-12.
  20. ^ Commissioner, Office of the (2019-02-13). "FDA permits marketing of two devices that detect parathyroid tissue in real-time during surgery". FDA. Retrieved 2019-08-15.
  21. ^ a b "Vanderbilt Biophotonics Center collaboration seeks earlier diagnosis of throat cancer". Vanderbilt University. Retrieved 2019-08-12.
  22. ^ "Anita Mahadevan-Jansen - Google Scholar Citations". scholar.google.com. Retrieved 2019-08-15.
  23. ^ "Conference Detail for Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry". spie.org. Retrieved 2019-08-15.
  24. ^ "Anita Mahadevan-Jansen - 2007 SPIE Women in Optics Planner". spie.org. Retrieved 2019-08-15.
  25. ^ "Equity, Diversity, and Inclusion Committee". spie.org. Retrieved 2019-08-12.
  26. ^ "Anita Mahadevan-Jansen SPIE Profile". spie.org. Retrieved 2019-08-11.
  27. ^ "Mahadevan-Jansen elected a director of international optics society". Vanderbilt University. Retrieved 2019-08-12.
  28. ^ "Anita Mahadevan-Jansen Mahadevan-jansen Elected Chair of Gordon Research Conference - AIMBE". Retrieved 2019-08-11.
  29. ^ "OSA 2018 Fellows". osa.org.
  30. ^ "Anita Mahadevan-Jansen, Ph.D. COF-1447 - AIMBE". Retrieved 2019-08-12.
  31. ^ "Video: Anita Mahadevan-Jansen on teaching and learning in biophotonics". spie.org. Retrieved 2019-08-15.
  32. ^ "Professors Jansen: A story of life, love and research". Vanderbilt University. Retrieved 2019-08-15.
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